My Strat is humming?!?!

I have a 2000 american stratocaster and it's humming. It doesn't hum if I turn the tone nobs all the way down though. Pickups are standard except at the bridge I have a doublestacked dimarzio humbucker. Any thoughts to kill the buzzing but still be able to turn the tone nobs up?

Are there noiseless pickups or only those that came with the american guitar? I heard that Kinmann pickup set for about 300$ is noiseless.
Is your startocaster HSS?

The pickups are the ones that came with the guitar for the neck and middle. The bridge pickup is a Dimarzio double stacked humbucker and it has the same problem.

You can possibly try cleaning the electronics with deoxit or changing the strings...you'd be amazed what that can do. If that doesn't work you may either have to change the pups or possibly replace a bad switch or pot something. You may have to just take it to a tech but try cleaning it first.

also check to make sure there aren't any bad solders and check to make sure the bar on the jack is connecting strongly when you plug it in. Sometimes those get loose and it breaks up the signal. Easy fix...just bend the bar in a little. Look for simple solutions first before you start dropping coin.

Yeah, the most common cause for that is a problem with the jack - it could just be dirty, or a bad connection (as Anubis described). As mentioned, try giving everything a good clean before anything else, and make sure your leads are good (I've seen so many guitarists have problems caused by cheap, nasty leads). Otherwise it's probably a bad solder.

It could be the lighting in that room, or other things plugged into that room's electrical circuit (laptop or other goodies). It's not entirely about the guitar's pickups, or shielding in the body.

Did you find the problem? It must be crappy wiring (or a bad solder) somewhere. Either in the jack or maybe the selector switch. Just curious.